Gemini III (Molly Brown)...very significant as it was the first spacecraft able to change its orbital plane and do maneuvers. Everybody else before it was pretty much just cargo.
Gemini III saw the use of the Titan II for a crewed launch. The Titan II uses hypergolic fuel for its booster engines...very dangerous as later flights found out.
https://en.wikipedia.org/wiki/Gemini_3
Gus Grissom and John Young were at the controls. Infamous for its 'corned beef on ry
Venera Program
https://en.wikipedia.org/wiki/Venera
Soviet missions to Venus.
Only the Soviets/Russians managed to get any surface time on the Solar System's most hostile planet. Eleven & Twelve were failures.
https://en.wikipedia.org/wiki/Venera_9
https://en.wikipedia.org/wiki/Venera_10
https://en.wikipedia.org/wiki/Venera_11
https://en.wikipedia.org/wiki/Venera_12
https://en.wikipedia.org/wiki/Venera_13
https://en.wikipedia.org/wiki/Venera_14